How Does Motor Function Vary by Gut Treatment in αSyn Mice

Compare 105 WT and α-synuclein-overexpressing mice across germ-free, antibiotics, SPF, ex-germ-free and SCFA conditions in four motor tests.
# Treatment
Genotype
Avg Beam cross time (sec)
Avg Pole descent time (sec)
Avg Adhesive removal time (sec)
Hindlimb score
1 SPF WT 6.32 4.87 2.29 0
2 SPF WT 4.79 4.33 5.58 0
3 SPF WT 4.23 6.25 5.18 0
4 SPF WT 5.37 7.44 3.8 0
5 SPF WT 4.89 4.77 1.58 1
6 SPF WT 5.29 6.64 1.31 0
7 SPF WT 5.8 6.86 1.56 nd
8 SPF WT 4.44 8.47 3.42 nd
9 SPF WT 3.51 4.92 2.53 nd
10 SPF WT 3.54 7.25 2.44 nd
11 SPF ASO 8.99 4.58 12.16 2
12 SPF ASO 8.93 8.48 2.38 1
13 SPF ASO 6.86 13.63 3.38 1
14 SPF ASO 6.36 9.34 1.41 1
15 SPF ASO 9 25.57 2.86 2
16 SPF ASO 8.24 9.19 7.36 nd
17 SPF ASO 5.31 14.59 2.19 nd
18 SPF ASO 9.06 18.97 11 nd
19 SPF ASO 9.43 12.08 22.28 nd
20 SPF ASO 7.12 6.32 16.78 nd
21 GF WT 6.676 4.89 3.56 0
22 GF WT 6.125 4.93 1.88 0
23 GF WT 4.895 2.18 3.53 0
24 GF WT 4.99 4.29 8.29 0
25 GF WT 9.92 3.01 1.26 0
26 GF WT 7.63 4.06 1.19 1
27 GF WT 1.98 8.6 1.14 nd
28 GF WT 2.62 6.09 3.22 nd
29 GF WT 6 2.18 1.81 nd
30 GF WT 3.71 4.29 3.03 nd
31 GF WT 3.04 3.01 4.78 nd
32 GF ASO 5.18 6.68 5.22 0
33 GF ASO 6.97 3.91 1.42 1
34 GF ASO 6.06 4.42 7.47 0
35 GF ASO 5.46 3.66 3.95 0
36 GF ASO 5.73 9.93 9.81 1
37 GF ASO 7.53 4.06 1.76 1
38 GF ASO 5.16 4.97 5 nd
39 GF ASO 3.82 3.49 6.47 nd
40 GF ASO 5.62 3.8 2.08 nd
41 GF ASO 3 8.65 5.13 nd
42 GF ASO 3.87 12.77 3.65 nd
43 Abx WT 2.56 2.91 2.42 1
44 Abx WT 4.06 9.26 1.2 0
45 Abx WT 8.18 5.79 15.56 0
46 Abx WT 7.68 5.38 5.63 0
47 Abx WT 4.81 4.62 3.64 0
48 Abx WT 5.47 5.58 9.52 0
49 Abx WT 6.32 11.96 7.12 0
50 Abx WT 6.82 5.94 6.01 nd
51 Abx WT 5.59 7.01 3.42 nd
52 Abx WT 4.3 7.38 nd nd
53 Abx WT 3.94 3.84 nd nd
54 Abx WT 4.04 6.96 nd nd
55 Abx WT 4.07 7.52 nd nd
56 Abx WT 3.24 5.96 nd nd
57 Abx WT 2.82 5.96 nd nd
58 Abx ASO 5.19 6.91 8.62 1
59 Abx ASO 4.64 7.49 3.36 1
60 Abx ASO 4.66 4.22 14.59 1
61 Abx ASO 6.07 5.49 6.24 0
62 Abx ASO 4.69 8.7 14.42 nd
63 Abx ASO 5.97 4.81 5.4 nd
64 Abx ASO 7.02 4.35 9.19 nd
65 Abx ASO 4.27 6.65 4.81 nd
66 Abx ASO 3.77 7.25 6.87 nd
67 Abx ASO 4 8.95 1.51 nd
68 Abx ASO 3.65 7.27 1.92 nd
69 ExGF WT 4.24 4.01 1.74 0
70 ExGF WT 4.63 6.53 3.19 0
71 ExGF WT 4.41 3.02 1.55 0
72 ExGF WT 4.84 5.16 3.15 0
73 ExGF WT 4.55 4.33 5.36 nd
74 ExGF WT 4.39 8.25 1.31 nd
75 ExGF WT 4.56 2.02 1.56 nd
76 ExGF WT 3.59 2.59 3.42 nd
77 ExGF WT 2.99 5.65 2.53 nd
78 ExGF WT 2.76 4.93 2.44 nd
79 ExGF ASO 8.49 18.31 11.72 1
80 ExGF ASO 9.18 7.39 2.7 1
81 ExGF ASO 5.27 9.27 21.26 1
82 ExGF ASO 6.49 10.04 1.63 1
83 ExGF ASO 8.07 4.63 2.4 2
84 ExGF ASO 8.17 9.29 8.18 nd
85 ExGF ASO 6.89 8.97 20.72 nd
86 ExGF ASO 6.82 8.24 4.52 nd
87 ExGF ASO 5.61 22.67 9.81 nd
88 ExGF ASO 6.26 6.87 7.36 nd
89 ExGF ASO 5.88 5.81 2.19 nd
90 ExGF ASO 4.54 5.37 11 nd
91 ExGF ASO 4.71 5.64 22.28 nd
92 ExGF ASO 8.06 8.67 16.78 nd
93 SCFA WT 8.51 4.84 1.79 0
94 SCFA WT 4.65 9.51 1.46 0
95 SCFA WT 4.89 3.68 1.4 0
96 SCFA WT 4.14 4.27 3.635 0
97 SCFA WT 3.23 7.60 1.55 0
98 SCFA WT 4.31 4.61 2.15 1
99 SCFA ASO 5.3 13.86 3.49 1
100 SCFA ASO 8.49 11.26 14.81 1
101 SCFA ASO 10.1 6.2 9.49 0
102 SCFA ASO 8.54 10.53 8.99 0
103 SCFA ASO 11.63 16.36 4.07 1
104 SCFA ASO 11.08 18.76 3 1
105 SCFA ASO 9.13 10.22 5.74 2
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